GLUCOCORTICOIDS PROMOTE TRANSITION OF DUCTAL CARCINOMA IN SITU TO INVASIVE DUCTAL CARCINOMA BY INDUCING MYOEPITHELIAL CELL APOPTOSIS

Glucocorticoids promote transition of ductal carcinoma in situ to invasive ductal carcinoma by inducing myoepithelial cell apoptosis

Abstract Background The microenvironment and stress factors like glucocorticoids have a strong influence on breast cancer progression but their role in the first stages of breast cancer and, particularly, in myoepithelial cell regulation remains unclear.Consequently, we investigated the role of glucocorticoids in ductal carcinoma in situ (DCIS) in

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QL1604 combined with bevacizumab as an innovative first-line treatment for HCC patient with extensive metastasis who showed remarkable effect: a case report

Hepatocellular carcinoma (HCC) is a common and highly malignant tumor with poor outcomes, especially when it metastasizes.In this report, we present the case of a 64-year-old male patient diagnosed with recurrence and multiple metastases of HCC 7 years after surgery.As the tumor invaded the spinal canal and pressed on the spinal cord, the patient e

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Exploitation of other social amoebae by Dictyostelium caveatum.

Dictyostelium amoebae faced with starvation trigger a developmental program during which many cells aggregate and form fruiting bodies that consist of a ball of spores held aloft by a thin stalk.This developmental strategy is open to several forms of exploitation, including the remarkable case of door kit Dictyostelium caveatum, which, even when it

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